| Pathway Id | ko03450 |
| Class & Sub-Class | Class: Genetic Information Processing Sub-Class: Replication and repair |
| Description | Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends; recruitment of DNA-PKcs (MRX complex in yeast); processing of ends; and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex; which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase); whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle; bringing about the ligation of two DNA DSBs without the need for sequence homology; and so is error-prone. Source: KEGG Database |
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